what is Amisulpride

what is Amisulpride

Brand name: Amipride

Active element: Amisulpride

Amipride is demonstrated in the treatment of psychosis and, in particular, acute and recurrent schizophrenia marked by positive (e.g., delusions, hallucinations, mental disturbances) and negative (e.g., blunt feelings, cognitive and social recessions), even in the case of prevalent negative symptoms.


In acute and chronic schizophrenia, Amipride is used with positive (hallucinating) and negative (retired or subdued) signs, emotions, seeings, and hearings that are not there; unusual and anxious thoughts, behavior changes.


A carbamate with hypnotic, sedative, and relaxing properties of the body, although it can induce muscle relaxation in therapeutic doses, alleviate anxiety rather than directly affect it. Anti-convulsive practices against small mal seizures, but not against major male bouts (which may be exacerbated), have been recorded for Amipride. It was applied to combat anxiety disorders, but it has been resolved mainly by benzodiazepines and the short-term treatment of insomnia. Amipride is a regulated ingredient in the United States.



It usually will be treated as a single daily consumption if the daily dosage is ~400 mg. Two daily intakes will occur if the daily dose reaches 400 mg.

Overwhelmingly negative episodes

The recommended dose is 50 to 300 mg/day. Dosage on an individual basis should be changed. The best amount is approximately 100 mg/day.

Excellent and negative mixed episodes

The dose should be the one that allows for the management of positive symptoms, i.e., 400 to 800 mg/day at the beginning of treatment. The dosage should then be changed individually to achieve the least effective dosage based on the patient’s response.

Acute psychotic episodes

It is possible to start with an IM route at a maximum dose of 400 mg/day, at the start of treatment, for several days, and then move to oral therapy. The dosage through the mouth is recommended to be 400 to 800 mg, with a maximum dosage of 1200 mg. Then, according to the patient’s response, the dose should be maintained and modified. In both cases, a minimum sufficient amount of the maintenance drug should be calculated separately.


The effectiveness and protection of Amipride have not been proven in pediatric patients from puberty to 18 years of age. There are limited details available on Amipride use in teenagers in schizophrenia. Therefore, it is not advisable to use Amipride from puberty to 18 years; Amipride is contraindicated in children up to puberty.

Hepatic impairment

Amipride is low metabolized, so the dosage in hepatic insufficiency patients does not need to be decreased.

Renal impairment

The renal path eliminates Amipride. In patients with creatinine clearance (CRCL) from 30 to 60 mL/min, the dose should be cut to half in renal failure, and in patients with CRCL to one-third about 10 to 30 mL/min.

Safety Tips 


With Amipride 50 Tablet, it is insecure about drinking alcohol.


Amipride 50 Tablet may be dangerous to use. While humans have limited research, the effects of animal experiments on the developmental baby have been adverse. Before you are prescribed, the doctor will assess all advantages and possible risks. Your doctor, please talk.


Amipride 50 Tablet may be dangerous in breast-feeding. Limited human data indicate that the medication will penetrate the breast milk and affect the infant.


In patients with kidney disease, Amipride 50 Tablet should be used with caution. Amipride 50 Tablet dose adjustment may be required. Your doctor, please talk. In patients with significant kidney disease, the use of Amipride 50 Tablet is not indicated.


Amipride 50 Tablet is likely to be safe for use in liver disease patients. Limited available data indicate that Amipride 50 Tablet dose adjustment in these patients may not be appropriate. Your doctor, please talk.


Amipride 50 Tablet can cause side effects that can impair your driving skills. When you take this medication, you may feel less alert, sleepy, or tired.


If you think you or someone else may have taken too much AMIPRIDE, call your doctor or poisons Information Center immediately or head to the nearest hospital for Accident and Emergency. Do so, even though no symptoms of poisoning occur. Medical treatment may be urgently required.

You can feel drowsy or slurred in speech if you take too much AMIPRIDE.

Missed dose 

Skip the missed dose and take the next amount when expected.

If not, take the missed dose as soon as you recall and then return to your tablets as usual.

Don’t ever make up for the missed dose in a double dose.

Ask your pharmacist or doctor if you are unsure of what you are doing.

Side effects 

  • Fever
  • Excessive Sweating
  • Change in Heart Rate
  • Severe Chest Pain
  • Swelling, Pain, and Redness in the Legs
  • Increased Frequency of Infections
  • Severe Skin Allergy
  • Seizures
  • Restless Legs
  • Twitches in the Tongue and Face
  • Trembling
  • Excessive Salivation
  • Constipation
  • Decreased Libido
  • Weight Gain
  • Amenorrhea
  • Gynecomastia
  • Agitation
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